Hematopoietic System
Instructions
List three classes of drugs affecting the Hematopoietic System. List the mechanism of action for each class of drug. Choose one medication from the three classes and discuss what disorder the drug is used to treat? How often the medication is given? What labs should get monitored while the patient is taking this medication?
Answer
Hematopoietic SystemClasses of Drugs Affecting Hematopoietic SystemAnticoagulantsAntiplatelet agentsThrombolyticsMechanism of Action of the DrugsAnticoagulantsThere are types types of anticoagulants including indirect thrombin inhibitor and direct thrombin inhibitors. Heparin is an indirect thrombin inhibitor. It binds to antithrombin III to change its conformation, expose its active site and enables rapid formation of Antithrombin III-Protease complexes. Heparin-Antithrombin III complex binds to activated clotting factors (proteases) preventing clot formation. Direct thrombin inhibitors such as argatroban and lepirudin inhibit thrombin binding to fibrinogen interrupting coagulation cascade. Warfarin inhibit epoxide hydralase, interfere with synthesis of vitamin K and thus interrupting act...
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