pathophysiology

Instructions

Go to the WCU Library and search the database for the following article. Read the article, and then answer the questions that follow: Soriano S., Alonso-Magdalena P., Garca-Arevalo M., Novials A., & Muhammed S. J. (2012). Rapid insulinotropic action of low doses of Bisphenol-A on mouse and human islets of langerhans: Role of estrogen receptor b. PLoS ONE 7(2): e31109. doi:10.1371/journal.pone.00311091.What are the causes of type 2 diabetes?2.What is the relationship between insulin resistance and hyperinsulinemia?3.What are endocrine disrupters and what are their functions in our body? Provide some examples.4.How does concentration of glucose effect insulin secretion?5.Explain how data from article support or refute the hypothesis that endocrine disrupters can change insulin secretion. Be sure to cite the article in text. Paraphrase key points from the article that support your answers.

Answer

Patho-physiology1. What are the causes of type 2 diabetesThe occurrence of type 2 diabetes is linked to the exposure to endocrine disruptor chemicals such as Bisphenol A (BPA) that impact negatively on glucose metabolism and also on the function of the pancreatic cells involved in insulin secretion. BPA induces an insulin-resistance state by impairing the secretion of insulin from the pancreatic cells (Soriano et al., 2012). Regulation of blood glucose is likely to be affected negatively as well since insulin is produced in low amounts. Furthermore, glucose metabolism is impaired since BPA also interfere with the release of adiponectin from the adipocytes increasing the chances of an individual succumbing to type 2 diabetes.2. What is the relationship betw...
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