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I have re-written a paragraph for you as an example. Could you use this as an example for the rest of the text? you will find some questions as Novels and there is website mention ( Macrophages and their marker). Could you please follow what I need and you can look on google some details.  Cathepsins are lysosomal proteases that have been implicated in tumour cell growth, invasion and metastasis as well as angiogenesis. Previous work in our laboratory (Wilkinson et al, 2015) has shown that cathepsin S (CatS) is a transcriptional regulator of a critical macrophage chemokine, chemokine (C-C motif) ligand 2 (CCL2). Through interaction with the CCR2 receptor on macrophages, CCL-2 can promote the recruitment of macrophages from the peripheral blood supply into tumour masses. Macrophages serve seemingly dichotomous roles in tumour development, with reports suggesting macrophages can be both pro-tumorigenic and anti-tumorigenic. These two disparate phenotypes have been termed M1 (anti-tumorigenic) and M2 (pro-tumorigenic) and the macrophage phenotype observed in a tumour is determined by a complex network of signaling chemokines and environmental stressors such as hypoxia. Previously, CCL2 has been reported to promote macrophage differentiation to the M2, pro-tumorigenic, phenotype (Roca, 2009). Given our previous studies demonstrating a role for CatS in CCL2 transcription, we postulated that pharmacological inhibition of CatS could prevent macrophage differentiation to the M2 phenotype resulting in polarization to a more favorable M1 phenotype. The key aims of this study are as follows:     Using novel inhibitors of CatS, demonstrate that CatS inhibition reduces the secretion of CCL2 from tumour epithelial cells in murine and human models    Using pre-determined M1/M2 macrophage differentiation markers (https://www.bio-rad-antibodies.com/macrophage-m1-m2-tam-tcr-cd169-cd-markers-antibodies.html), evaluate the role of CatS inhibition on macrophage differentiation`        Using previously published in vivo models, determine the role of CatS inhibition on Macrophage differentiation and recruitment into tumour masses. 

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